Frasier’s Famous Friends: 24 Incredible Cameos To Remember

Frasier Crane

I've been a fan of Frasier since the '90s. I've always loved the characters, their distinct personalities, and their clever interactions. When the sitcom concluded in 2004 after a remarkable eleven-season run, fans like me were grateful for reruns and Facebook groups where we could discuss our favorite episodes and characters until the long-awaited reboot kicked off in 2023.

Given the show's history of featuring famous voices as radio guests and celebrity appearances, here are some memorable ones you might recall from the original series. Or did you miss some of these?

1. Robbie Coltrane

Robbie Coltrane
Image Credit: Featureflash Photo Agency/Shutterstock.

Robbie Coltrane was a renowned Scottish actor best known for his iconic portrayal of Rubeus Hagrid in the Harry Potter franchise. He won three consecutive awards for his portrayal of the character Fitz in the British crime series Cracker. He had a cameo role on Frasier as Daphne's brother, Michael Moon. 

2. Jennifer Beals

Flashdance 1983 Jennifer Beals
Image Credit: Paramount Pictures.

Jennifer Beals is celebrated for her breakthrough role in the 1983 film Flashdance. She gained fame for portraying Bette Porter in the TV series The L Word. The actress appears as Dr. Anne Ranberg in several Frasier episodes.

3. David Duchovny

David Duchovny
Image Credit: Joe Seer / Shutterstock.

David Duchovny, known for “The X-Files,” played “Tom,” a caller who rings Frasier's radio show to ask if there should be more to a relationship than just adult relations. In addition to his acting career, Duchovny is also a writer and musician, contributing to his multifaceted artistic pursuits.

4. Sir Patrick Stewart

Frasier, The Doctor Is Out, Patrick Stewart
Image Credit: Paramount Network Television.

Sir Patrick Stewart is a distinguished English actor known for portraying Captain Jean-Luc Picard in the Star Trek: The Next Generation series and subsequent films. His extensive acting career includes a wide range of roles in theater, film, and television, earning him critical acclaim and recognition as one of the finest actors of his generation. He appeared as opera director Alistair Burke in Frasier.

5. Ben Stiller

Zoolander (2001)
Image Credit: Paramount Pictures.

Ben Stiller is a versatile American actor, comedian, and filmmaker renowned for his roles in comedy films such as There's Something About Mary and Meet the Parents. His voice can be heard in a cameo during season one as a caller on Frasier's show.

6. Dame Helen Mirren

Helen Mirren 2208 cropped scaled e1696444255589
Image Credit: Wiki Commons, By Harald Krichel – Own work, CC BY-SA 3.0.

The highly acclaimed British actress is known for her versatile and award-winning performances on stage and screen. Her remarkable career includes iconic roles in films like The Queen and The Last Station.  Frasier is fascinated by a call he receives to his show from Babette, a softly spoken kleptomaniac voiced by the Oscar-winning actress. During their interaction, Babette confesses that despite her mundane life, she finds excitement in the inexplicable act of stealing random items.

7. Linda Hamilton

Linda Hamilton
Image Credit: Paramount Pictures.

Linda Hamilton, known for the Terminator films, played Laura, a cello player Frasier meets at an airport bar. She also had a secondary role as a caller, Claire, on Frasier's radio show. 

8. Laura Linney

Frasier, Detour, Kelsey Grammer, Laura Linney
Image Credit: Paramount Network Television.

Laura Linney is a versatile American actress known for her exceptional film, television, and theater performances, earning her multiple award nominations and critical acclaim. She plays the recurring character of a matchmaker named Charlotte in season 11, whom Frasier falls for. 

9. Brian Cox

Brian Cox
Image Credit: lev radin/Shutterstock.

Brian Cox is a highly esteemed Scottish actor known for his extensive and versatile career. He has notable roles in film and theater, including portrayals of historical figures such as Winston Churchill in Churchill (and Logan Roy in the TV series Succession.) He also played Daphne Moon's elusive father in Frasier.

10. Rosie Perez

Rosie Perez
Image Credit: lev radin/Shutterstock.

Rosie Perez is known for her vibrant performances on screen in Do the Right Thing and Your Honor and her work as a choreographer and dancer. She played Roz's friend Lisbeth in the series, an obnoxious character with whom Roz wants to set Frasier up. Notably, Perez was the original choice for the role of Daphne. 

11. Teri Hatcher

Desperate Housewives (2004)
Image Credit: Touchstone Television.

Teri Hatcher, of Desperate Housewives fame, had a memorable role as a date of Frasier's. She played Marie, the daughter of Martin Crane's friend, Duke. While Frasier falls for Marie, he starts to suspect that she's only interested in him for free therapy. 

12. John Cusack

better off dead
Image Credit: Warner Bros.

John Cusack made a brief cameo as a caller to Frasier's radio show. He portrays Greg, a first-year graduate student in psychology with a quirky twist – he's mistakenly diagnosed himself with every disorder he's studying. Cusack is best known for his diverse roles in films spanning various genres, from the romantic comedy Serendipity to the dark comedy Being John Malkovich.

13. Rita Wilson

Rita Wilson
Image Credit: lev radin/Shutterstock.

Actress and singer Rita Wilson appeared in reminiscing scenes as Martin Crane's deceased wife, Hester Crane. She also appears briefly as Frasier's girlfriend, Mia, until he realizes how much she looks like his mother. 

14. Jodie Foster

contact 1997
Image Credit: Warner Bros.

Jodie Foster is known for her ability to portray a wide range of complex and memorable characters in movies such as The Silence of the LambsTaxi Driver, and Panic Room, among others, earning her multiple Academy Awards and critical acclaim. Foster plays a radio show caller, Marlene, in Frasier, who complains she never has time for intimate relations with her husband.

15. Bob Hoskins

Bob Hoskins
Image Credit: Paramount Network Television.

Bob Hoskins was a versatile British actor who gained fame for portraying Eddie Valiant in Who Framed Roger Rabbit. He showcased his skill in depicting diverse characters on big and small screens. This included a cameo as Coach Fuller, a squash coach Frasier had previously had issues with. 

16. Jean Smart

Flashpoint
Image Credit: Tri-Star Pictures.

Jean Smart is a talented American actress known for her versatile roles in both television and film. She has appeared in various popular TV series and movies throughout her career. Notable works include her roles in TV series like FargoDesigning Women, 24, and Hacks, for which she received critical acclaim. She played Frasier's high school crush, Lana Gardner.

17. Anthony Lapaglia

Frasier, Dark Side of the Moon, Anthony LaPaglia
Image Credit: Paramount Network Television.

Australian-born actor Anthony LaPaglia appeared as Simon, another of Daphne's brothers. He had a recurring role for a number of episodes, and his attempt at a Manchester accent is probably one of the most hated amongst fans. 

18. Richard E Grant

Richard E Grant
Image Credit: Fred Duval/Shutterstock.

Richard E. Grant is famous for his remarkable performances in Withnail and I, Can You Ever Forgive Me?, and his role in the Star Wars series The Rise of Skywalker. Appearing in the same episode with Robbie Coltrane, he played another of Daphne's brothers, Stephen Moon.

19. Virginia Madsen

Electric Dreams
Image Credit: MGM/UA Entertainment Co.

Academy Award-nominated actress Virginia Madsen is known for her diverse roles in film and television, notably in Sideways, as well as in TV series like Designated Survivor. She appeared in three episodes of Frasier as a love interest, Cassandra Stone. 

20. Lily Tomlin

Lily Tomlin
Image Credit: Kathy Hutchins/Shutterstock.

Lily Tomlin started as a stand-up comedian in the '60s and went on to perform in numerous stage, TV, and film roles, such as Grace and Frankie, and the '70s skit show Rowan and Martin's Laugh-In. Not only can her voice be heard as the iconic Ms. Frizzle in The Magic School Bus but as the voice of caller Rita on Frasier's show. After telling him how overwhelmed she feels, he suggests she gets a puppy.

21. Carrie Fisher

Carrie Fisher
Image Credit: Lucasfilm.

The Star Wars actress made a guest appearance on Frasier‘s radio show. Her character, Phyllis, sought advice on managing insomnia, but unfortunately for her, both Frasier and Roz dozed off and missed her call.

22. Bill Gates

Image of Bill Gates
Image Credit: Shutterstock.

The Microsoft founder appeared for the 200th episode of Frasier. Callers to the radio show's fictional 2000th episode are able to speak with Gates and Crane, but Frasier is forgotten for the business mogul as callers pepper him with questions about Microsoft. 

23. Michael Keaton

Michael Keaton
Image Credit: Shutterstock.

The Batman and Beetlejuice actor and comedian appears as a wheel-chair bound Blaine Sternin, Frasier's ex-brother-in-law. Previously a shady character who always had a scheme or two going, Sternin claims to have found God, but Frasier is suspicious. 

24. Dr. Phil

Dr. Phil
Image Credit: Joe Seer / Shutterstock.com.

The famous talk show host, Phil McGraw, appears as himself. Frasier's agent, Bebe Glazer, reveals that she's also Dr. Phil's agent. Frasier claims to have known Dr. Phil previously and says that he owes him $200 from a card game. 

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